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Accufine is a brand name for isotretinoin capsules, a medication used to treat severe acne. It is a retinoid, which means it is related to vitamin A. Isotretinoin works by reducing the amount of oil produced by the skin, which helps to prevent acne. Accufine Uses Isotretinoin is used to treat severe nodular or cystic acne that has not responded to other treatments, such as antibiotics. Benefits: Can be very effective in clearing severe acne. May provide long-lasting remission from acne after treatment is complete. Important information: Isotretinoin is a powerful medication with potentially serious side effects. It is crucial to be under the care of a dermatologist (a doctor specializing in skin conditions) while taking it. Do not use isotretinoin without a doctor's prescription and close monitoring.